AOBiome announces appointment of scientific advisory board

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AOBiome announces appointment of scientific advisory board

19 May 2014, Cambridge, MA
AOBiome, a company pioneering potentially transformative healthcare products based on modulating the skin microbiome, announced today the establishment of a Scientific Advisory Board to help guide the company’s programs for developing proprietary probiotic cosmetics to enhance skin health and novel therapeutics to prevent or treat skin and inflammatory diseases.

“AOBiome is building on the rapidly emerging science of the skin microbiome to advance a new category of skin products by applying “good bacteria” to restore the natural, protective balance of skin microbes,” said Spiros Jamas, ScD, CEO of AOBiome. “We have assembled world leaders in genomics and sequencing; dermatology; nitric oxide biology; immunology; and wound healing physiology to help guide the company’s efforts. We look forward to many contributions from this distinguished group.”

AOBiome’s lead probiotic oxidizes ammonia, which is abundant in sweat, to produce nitrite and nitric oxide, which are essential to good health. “These ammonia oxidizing bacteria (AOB) have been eliminated by most soaps and frequent use of antibiotics. Reintroducing AOB may provide important benefits by restoring the natural balance of formation and degradation of nitric oxide needed to regulate key pathways known to be perturbed in skin and inflammatory diseases,” commented Martin Feelisch, PhD, Professor of Experimental Medicine and Integrative Biology at the University of Southampton (UK).

Members of the AOBiome Scientific Advisory Board include:
George Church, PhD, Professor of Genetics, Harvard Medical School, Professor of Health Sciences and Technology at Harvard and MIT Martin Feelisch, PhD, Professor of Experimental Medicine and Integrative Biology at the University of Southampton (UK). Howard Maibach, MD, Professor of Dermatology, UCSF School of Medicine Dean Ornish, MD, Founder & President of the nonprofit Preventative Medicine Research Institute and Clinical Professor of Medicine, University of California San Francisco Derya Unutmaz, MD, Professor of Microbiology, Pathology and Medicine, Director of Human Immunology & shRNA Core, NYU School of Medicine Aristidis Veves, MD, DSc, Professor, Harvard Medical School; Research Director, Microcirculation Lab & Joslin-Beth Israel Deaconess Foot Center Larry Weiss, MD, Founder & Chief Scientist, CleanWell Company

About AOBiome
AOBiome LLC is developing a transformative, new class of products based on Ammonia Oxidizing Bacteria (AOB) to improve skin health and prevent or treat skin and inflammatory diseases. The company’s probiotics are designed to provide cosmetic and therapeutic benefits by restoring the natural, protective balance afforded by beneficial skin microbes that have been lost due to modern living practices, including antibiotic use, soaps, and shampoos. AOB are ubiquitous bacteria that use oxidize ammonia and urea, two components in sweat, to nitrite, an anti-microbial compound, and nitric oxide, an important signaling molecule that helps the body manage skin and systemic functions. AOBiome is developing cosmetics and a pipeline of skin therapeutics to treat diabetic ulcers, acne and atopic dermatitis.

The company was established in 2013 by its scientific founder, David Whitlock; biotech entrepreneur James Heywood, Co-founder of PatientsLikeMe and Founder of the ALS Therapy Development Institute; Lenny Barshack, a serial entrepreneur of technology companies; and Dr. Jamas.

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